Departments of Basic Medical Science and Anesthesiology, School of Medicine, University of Missouri-Kansas City, 2411 Holmes Street, Room M3-417, Kansas City, MO, 64108-2792, USA,
Transl Stroke Res. 2014 Feb;5(1):69-78. doi: 10.1007/s12975-013-0305-y. Epub 2013 Nov 16.
Acidosis that occurs under pathological conditions not only affects intracellular signaling molecules, but also directly activates a unique family of ligand-gated ion channels: acid-sensing ion channels (ASICs). ASICs are widely expressed throughout the central and peripheral nervous systems and play roles in pain sensation, learning and memory, and fear conditioning. Overactivation of ASICs contributes to neurodegenerative diseases such as ischemic brain/spinal cord injury, multiple sclerosis, Parkinson's disease, and Huntington's disease. Thus, targeting ASICs might be a potential therapeutic strategy for these conditions. This mini-review focuses on the electrophysiology and pharmacology of ASICs and roles of ASICs in neuronal toxicity.
在病理条件下发生的酸中毒不仅会影响细胞内信号分子，还会直接激活一类独特的配体门控离子通道：酸敏感离子通道（ASICs）。ASICs 在中枢和外周神经系统中广泛表达，在痛觉、学习和记忆以及恐惧条件反射中发挥作用。ASICs 的过度激活与神经退行性疾病有关，如缺血性脑/脊髓损伤、多发性硬化症、帕金森病和亨廷顿病。因此，针对 ASICs 可能是这些疾病的一种潜在治疗策略。这篇迷你综述重点介绍了 ASICs 的电生理学和药理学以及 ASICs 在神经元毒性中的作用。
