Children's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of New South Wales, Australia; Department of Haematology, SA Pathology, Adelaide, Australia.
IUBMB Life. 2013 Dec;65(12):999-1011. doi: 10.1002/iub.1233. Epub 2013 Dec 10.
The mechanisms by which cells control their growth and behavioral identities are complex and require adaptability to environmental changes. Transcription factors act as master controllers of many of these pivotal points through their ability to influence the expression of many thousands of downstream genes, and increasingly research is showing that transcription factor regulation of target genes can change in response to environmental stimuli and cell type such that their function is not prescribed but rather context-dependent. Krüppel like factor 5 (KLF5) is an example of such a transcription factor, where evidence of disparate effects on cell growth and differentiation in normal and transformed tissue are clear. Here we present and discuss the literature covering the differential roles of KLF5 in particular tissues and cancer states, and the mechanisms by which these differences are effected through the regulation of KLF5 protein function in response to different cellular states and the direct effect on target gene expression.
细胞控制其生长和行为特征的机制非常复杂，需要适应环境变化。转录因子通过影响数千个下游基因的表达，成为许多关键节点的主控器。越来越多的研究表明，转录因子对靶基因的调控可以根据环境刺激和细胞类型而发生变化，因此其功能不是预先确定的，而是依赖于上下文。Krüppel 样因子 5（KLF5）就是这样一个转录因子的例子，在正常组织和转化组织中，它对细胞生长和分化的影响明显不同。在这里，我们介绍并讨论了涵盖 KLF5 在特定组织和癌症状态下的差异作用的文献，并讨论了通过调节 KLF5 蛋白功能来应对不同细胞状态以及对靶基因表达的直接影响来实现这些差异的机制。
