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FLT3-ITD confers poor prognosis in patients with acute promyelocytic leukemia treated with AIDA protocols: long-term follow-up analysis.

作者信息

Breccia Massimo, Loglisci Giuseppina, Loglisci Maria Giovanna, Ricci Roberto, Diverio Daniela, Latagliata Roberto, Foà Robin, Lo-Coco Francesco

出版信息

Haematologica. 2013 Dec;98(12):e161-3. doi: 10.3324/haematol.2013.095380.

DOI:10.3324/haematol.2013.095380
PMID:24323990
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3856980/
Abstract
摘要

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FLT3-ITD confers poor prognosis in patients with acute promyelocytic leukemia treated with AIDA protocols: long-term follow-up analysis.FLT3-ITD在接受AIDA方案治疗的急性早幼粒细胞白血病患者中预后较差：长期随访分析。
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本文引用的文献

1
Clinical impact of FLT3 mutation load in acute promyelocytic leukemia with t(15;17)/PML-RARA.FLT3 突变负荷对伴有 t(15;17)/PML-RARA 的急性早幼粒细胞白血病的临床影响。
Haematologica. 2011 Dec;96(12):1799-807. doi: 10.3324/haematol.2011.049007. Epub 2011 Aug 22.
2
Prognostic value of FLT3 mutations in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline monochemotherapy.全反式维甲酸和蒽环类单药化疗治疗急性早幼粒细胞白血病患者中 FLT3 突变的预后价值。
Haematologica. 2011 Oct;96(10):1470-7. doi: 10.3324/haematol.2011.044933. Epub 2011 Jun 17.
3
Treatment outcome of all-trans retinoic acid/anthracycline combination chemotherapy and the prognostic impact of FLT3/ITD mutation in acute promyelocytic leukemia patients.全反式维甲酸/蒽环类药物联合化疗治疗急性早幼粒细胞白血病患者的疗效及FLT3/ITD突变的预后影响
Korean J Hematol. 2011 Mar;46(1):24-30. doi: 10.5045/kjh.2011.46.1.24. Epub 2011 Mar 15.
4
AIDA 0493 protocol for newly diagnosed acute promyelocytic leukemia: very long-term results and role of maintenance.AIDA 0493 方案治疗初发急性早幼粒细胞白血病：极长期结果和维持治疗的作用。
Blood. 2011 May 5;117(18):4716-25. doi: 10.1182/blood-2010-08-302950. Epub 2011 Mar 8.
5
Front-line treatment of acute promyelocytic leukemia with AIDA induction followed by risk-adapted consolidation for adults younger than 61 years: results of the AIDA-2000 trial of the GIMEMA Group.AIDA 诱导后适应风险的巩固治疗用于年龄小于 61 岁的成人急性早幼粒细胞白血病的一线治疗：意大利血液与骨髓移植组 AIDA-2000 试验的结果。
Blood. 2010 Oct 28;116(17):3171-9. doi: 10.1182/blood-2010-03-276196. Epub 2010 Jul 19.
6
Long FLT3 internal tandem duplications and reduced PML-RARα expression at diagnosis characterize a high-risk subgroup of acute promyelocytic leukemia patients.长的 FLT3 内部串联重复和诊断时 PML-RARα 表达减少的特征是急性早幼粒细胞白血病患者的一个高危亚组。
Haematologica. 2010 May;95(5):745-51. doi: 10.3324/haematol.2009.015073. Epub 2010 Feb 4.
7
Prognostic significance of FLT3 internal tandem duplication and tyrosine kinase domain mutations in acute promyelocytic leukemia: a systematic review.FLT3 内部串联重复和酪氨酸激酶结构域突变对急性早幼粒细胞白血病预后意义的系统评价。
Leuk Res. 2010 Jul;34(7):831-6. doi: 10.1016/j.leukres.2010.01.001. Epub 2010 Jan 21.
8
Relationship between FLT3 mutation status, biologic characteristics, and response to targeted therapy in acute promyelocytic leukemia.急性早幼粒细胞白血病中FLT3突变状态、生物学特征与靶向治疗反应之间的关系
Blood. 2005 Dec 1;106(12):3768-76. doi: 10.1182/blood-2005-04-1746. Epub 2005 Aug 16.
9
Alterations of the FLT3 gene in acute promyelocytic leukemia: association with diagnostic characteristics and analysis of clinical outcome in patients treated with the Italian AIDA protocol.急性早幼粒细胞白血病中FLT3基因的改变：与诊断特征的关联以及接受意大利AIDA方案治疗患者的临床结局分析
Leukemia. 2002 Nov;16(11):2185-9. doi: 10.1038/sj.leu.2402723.
10
Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: a study of the AML Study Group Ulm.激活的FLT3突变在年龄较轻（16至60岁）、细胞遗传学正常的急性髓系白血病成年患者中的预后意义：乌尔姆AML研究组的一项研究
Blood. 2002 Dec 15;100(13):4372-80. doi: 10.1182/blood-2002-05-1440. Epub 2002 Aug 8.