First description of the t(10;11)(q22;q23)/MLL-TET1 translocation in a T-cell lymphoblastic lymphoma, with subsequent lineage switch to acute myelomonocytic myeloid leukemia.
作者信息
Ittel Antoine, Jeandidier Eric, Helias Catherine, Perrusson Nathalie, Humbrecht Catherine, Lioure Bruno, Mazurier Isabelle, Mayeur-Rousse Caroline, Lavaux Amandine, Thiebault Sylvie, Lerintiu Felix, Gervais Carine, Mauvieux Laurent
出版信息
Haematologica. 2013 Dec;98(12):e166-8. doi: 10.3324/haematol.2013.096750.
Abstract
摘要
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First description of the t(10;11)(q22;q23)/MLL-TET1 translocation in a T-cell lymphoblastic lymphoma, with subsequent lineage switch to acute myelomonocytic myeloid leukemia.首次报道T细胞淋巴母细胞淋巴瘤中t(10;11)(q22;q23)/MLL-TET1易位，随后谱系转变为急性粒单核细胞白血病。
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The MLL recombinome of acute leukemias in 2013.2013 年急性白血病的 MLL 重排组。
Leukemia. 2013 Nov;27(11):2165-76. doi: 10.1038/leu.2013.135. Epub 2013 Apr 30.
2
NANOG-dependent function of TET1 and TET2 in establishment of pluripotency.NANOG 依赖的 TET1 和 TET2 功能在多能性建立中的作用。
Nature. 2013 Mar 21;495(7441):370-4. doi: 10.1038/nature11925. Epub 2013 Feb 10.
3
Genomic breakpoints and clinical features of MLL-TET1 rearrangement in acute leukemias.急性白血病中MLL-TET1重排的基因组断点与临床特征
Haematologica. 2013 Apr;98(4):e55-7. doi: 10.3324/haematol.2012.076323. Epub 2012 Oct 25.
4
Lineage switching in acute leukemias: a consequence of stem cell plasticity?急性白血病中的谱系转换：干细胞可塑性的结果？
Bone Marrow Res. 2012;2012:406796. doi: 10.1155/2012/406796. Epub 2012 Jul 19.
5
Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells.Tet1 和 Tet2 调节小鼠胚胎干细胞中 5-羟甲基胞嘧啶的产生和细胞谱系特化。
Cell Stem Cell. 2011 Feb 4;8(2):200-13. doi: 10.1016/j.stem.2011.01.008.
6
The MLL recombinome of adult CD10-negative B-cell precursor acute lymphoblastic leukemia: results from the GMALL study group.成人CD10阴性B细胞前体急性淋巴细胞白血病的MLL重组组：来自GMALL研究组的结果。
Blood. 2009 Apr 23;113(17):4011-5. doi: 10.1182/blood-2008-10-183483. Epub 2009 Jan 14.
7
MLL translocations, histone modifications and leukaemia stem-cell development.混合谱系白血病（MLL）易位、组蛋白修饰与白血病干细胞发育
Nat Rev Cancer. 2007 Nov;7(11):823-33. doi: 10.1038/nrc2253.
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Characterization of fusion partner genes in 114 patients with de novo acute myeloid leukemia and MLL rearrangement.114例初发急性髓系白血病伴MLL重排患者中融合伴侣基因的特征分析
Leukemia. 2006 Feb;20(2):218-23. doi: 10.1038/sj.leu.2404024.
9
TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23).TET1是一个新型蛋白质家族的成员，在含有t(10;11)(q22;q23)的急性髓系白血病中与MLL融合。
Leukemia. 2003 Mar;17(3):637-41. doi: 10.1038/sj.leu.2402834.
10
A study on 289 consecutive Korean patients with acute leukaemias revealed fluorescence in situ hybridization detects the MLL translocation without cytogenetic evidence both initially and during follow-up.一项针对289例连续性韩国急性白血病患者的研究显示，荧光原位杂交技术在初始阶段及随访期间均能检测到无细胞遗传学证据的MLL易位。
Br J Haematol. 2002 Dec;119(4):930-9. doi: 10.1046/j.1365-2141.2002.03937.x.
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