First Department of Surgery, University of Fukui, 23-3, Eiheiji-cho, Yoshida-gun, Fukui, Japan.
Anticancer Res. 2013 Dec;33(12):5311-5.
We studied prokineticin 1 (PROK1) expression in human gastrointestinal carcinomas by immunohistochemistry.
PROK1 expression was examined in human gastrointestinal cancer cell lines and primary gastrointestinal lesions. In addition the relationship between the number of blood vessels and PROK1 expression in these primary lesions was examined.
PROK1 expression was observed in gastrointestinal cancer cell lines. PROK1 expression was not observed in healthy gastrointestinal mucosa, but was observed in the primary lesions in 23 out of 98 (31.6%) patients with colorectal cancer, 19 out of 55 (34.5%) patients with gastric cancer, and 5 of 10 (50%) patients with cancer of the small intestine. PROK1 expression was observed in many patients with advanced gastrointestinal cancer. The number of blood vessels in PROK1-positive primary gastrointestinal lesions was higher than that in PROK1-negative primary lesions.
PROK1 expression might be related to the extent of malignancy in gastrointestinal cancer.
通过免疫组织化学方法研究人胃肠道癌中促动力素 1（PROK1）的表达。
检测 PROK1 在人胃肠道癌细胞系和原发性胃肠道病变中的表达。此外，还检测了这些原发性病变中血管数量与 PROK1 表达之间的关系。
在胃肠道癌细胞系中观察到 PROK1 表达。在健康的胃肠道黏膜中未观察到 PROK1 表达，但在 98 例结直肠癌患者中的 23 例（31.6%）、55 例胃癌患者中的 19 例（34.5%）和 10 例小肠癌患者中的 5 例（50%）原发性病变中观察到 PROK1 表达。在许多晚期胃肠道癌患者中观察到 PROK1 表达。PROK1 阳性原发性胃肠道病变中的血管数量高于 PROK1 阴性原发性病变。
PROK1 的表达可能与胃肠道癌的恶性程度有关。
