Terry Fox Cancer Research Lab, China Medical University Hospital, 2 Yuh-Der Road, Taichung, 404 Taiwan,
Anticancer Res. 2013 Dec;33(12):5401-5.
Bladder cancer is the sixth most common cancer worldwide and its incidence is particularly high in southwestern Taiwan. However, the genetic contribution to its etiology is not well-understood. The aim of this study is to evaluate the association of cyclooxygenase 2 (Cox-2) polymorphic genotypes with Taiwan bladder cancer patients.
Six polymorphic variants of Cox-2 were analyzed regarding their association with bladder cancer risk, and three hundred and seventy-five patients with bladder cancer and same amount of age- and gender-matched healthy controls recruited were genotyped by the PCR-RFLP method.
Among the six polymorphic sites examined, only the Cox-2 promoter G-765C (rs20417) genotypes were positively associated with bladder cancer risk (p=0.0102). Individuals with the Cox-2 -765GC genotypes were associated with higher prostate cancer risk than those with -765GG.
Our findings provide evidence that the C allele of Cox-2 promoter G-765C may be associated with the overexpression of COX-2 during bladder cancer development and may be a useful marker for the early detection of bladder cancer.
膀胱癌是全球第六大常见癌症，在台湾西南部的发病率尤其高。然而，其病因的遗传贡献尚不清楚。本研究旨在评估环氧化酶 2（Cox-2）多态性基因型与台湾膀胱癌患者的关联。
分析了 Cox-2 的 6 个多态性变体与膀胱癌风险的关联，并采用 PCR-RFLP 方法对 375 名膀胱癌患者和相同数量的年龄和性别匹配的健康对照者进行了基因分型。
在所检查的六个多态性位点中，只有 Cox-2 启动子 G-765C（rs20417）基因型与膀胱癌风险呈正相关（p=0.0102）。与 -765GG 相比，Cox-2-765GC 基因型个体患前列腺癌的风险更高。
我们的研究结果表明，Cox-2 启动子 G-765C 的 C 等位基因可能与膀胱癌发生过程中 COX-2 的过度表达有关，可能是膀胱癌早期检测的有用标志物。
