Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan.
Anticancer Res. 2013 Dec;33(12):5575-8.
Primary ocular adnexal mucosa-associated lymphoid tissue lymphoma (POAML) is a rare disease. The purpose of this study was to evaluate the treatment outcome and patterns of failure of patients with early-stage POAML treated with radiotherapy.
From 1995 to 2008, 53 patients with early-stage POAML were reviewed. Tumors were categorized as either superficial or mass-forming type. In principle, superficial lesions (n=11) were treated with 24 Gy, while the mass-forming lesions (n=42) were irradiated with 30 Gy. The median follow-up period was 3.9 years.
All four cases of relapse had mass-forming lesions. The 5-year overall and progression-free survival rates were 100% and 91.5%, respectively. Although 30 patients experienced grade 2 or 3 late adverse events, no patients had radiation-related retinopathy.
Early-stage POAML can be well-controlled with radiotherapy. However, the risk of distant relapse should be noted, in particular, for mass-forming tumors.
原发性眼附属器黏膜相关淋巴组织淋巴瘤（POAML）是一种罕见疾病。本研究旨在评估接受放疗的早期 POAML 患者的治疗结果和失败模式。
1995 年至 2008 年，回顾了 53 例早期 POAML 患者。肿瘤分为浅表型或肿块型。原则上，浅表病变（n=11）采用 24Gy 治疗，肿块型病变（n=42）采用 30Gy 照射。中位随访时间为 3.9 年。
所有 4 例复发患者均为肿块型病变。5 年总生存率和无进展生存率分别为 100%和 91.5%。尽管 30 例患者发生 2 级或 3 级晚期不良事件，但无患者发生放射性视网膜病变。
早期 POAML 可通过放疗得到良好控制。然而，应注意远处复发的风险，尤其是肿块型肿瘤。
