Department of Digestive and Oncological Surgery, Timone Hospital, Aix-Marseille University, Marseille, France
Anticancer Res. 2013 Dec;33(12):5645-8.
Brain metastases (BMs) from colorectal cancer are rare (2-3%). They usually occur in advanced stages of the disease and their prognosis is poor. The aim of this study was to assess the impact of surgical resection of BMs from colorectal cancer in terms of overall survival.
A retrospective bi-centric study included all patients with resected BMs from primary colorectal adenocarcinoma from 1998 to 2009.
Twenty-eight patients [13 males, median: 62 (range: 44-86) years old) were included. Fifteen patients presented with other metastatic sites (lung, liver). BMs were metachronous in 16/28 (57%) of patients [median: 19 months (range: 7-97)]. Median overall survival reached 12 months. Brain recurrences occurred in 32% of patients and were treated by curative intent in 5/9 cases.
When indicated, an aggressive management based on surgical resection of BMs from colorectal cancer, must be performed, in order to improve overall survival to at least 12 months.
结直肠癌脑转移（BMs）较为罕见（2-3%）。它们通常发生在疾病的晚期，预后较差。本研究旨在评估结直肠腺癌脑转移瘤手术切除对总生存期的影响。
这是一项回顾性的双中心研究，纳入了 1998 年至 2009 年间所有接受过原发性结直肠腺癌脑转移瘤切除术的患者。
共纳入 28 例患者[13 例男性，中位年龄 62 岁（范围：44-86 岁）]。15 例患者存在其他转移部位（肺、肝）。16/28（57%）例患者的 BMs 为异时性[中位时间为 19 个月（范围：7-97 个月）]。中位总生存期为 12 个月。32%的患者出现脑复发，并对 5/9 例患者进行了根治性治疗。
当有指征时，必须对结直肠腺癌脑转移瘤进行积极的手术治疗，以将总生存期至少提高至 12 个月。
