结直肠癌同步性和异时性脑转移的生存结局比较：一项荟萃分析。
Comparative survival outcome of synchronous and metachronous brain metastasis from colorectal cancer: A meta‑analysis.
作者信息
Tsai Tsung-Chiao, Song Junmin, Chi Kuan-Yu, Lin Hong-Min, Chang Yu
机构信息
Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan, R.O.C.
Department of Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, New York City, NY 10461, USA.
出版信息
Oncol Lett. 2025 Mar 17;29(5):233. doi: 10.3892/ol.2025.14979. eCollection 2025 May.
Synchronous and metachronous brain metastases (BM) are increasingly recognized in patients with colorectal cancer (CRC). This study aimed to assess whether the timing of BM development affects survival outcomes by conducting a systematic review and meta-analysis. A comprehensive search of the Cochrane Library, Embase and MEDLINE databases was performed, covering studies from January 1900 to December 2023. To compare survival outcomes between synchronous and metachronous BM, hazard ratios (HRs) for overall survival (OS) were extracted from the included studies and pooled using a random-effects model. The systematic review included nine retrospective cohort studies comprising 910 patients with BM from CRC. Meta-analysis results showed no significant difference in OS between patients with synchronous and metachronous BM (HR, 0.90; 95% confidence interval, 0.59-1.38; P=0.63). In conclusion, this meta-analysis suggests that the timing of BM development does not impact OS in patients with BM from CRC.
结直肠癌（CRC）患者中，同时性和异时性脑转移（BM）越来越受到关注。本研究旨在通过系统评价和荟萃分析，评估BM发生时间是否会影响生存结局。我们全面检索了考克兰图书馆、Embase和MEDLINE数据库，涵盖1900年1月至2023年12月的研究。为比较同时性和异时性BM患者的生存结局，从纳入研究中提取总生存（OS）的风险比（HR），并采用随机效应模型进行汇总。该系统评价纳入了9项回顾性队列研究，共910例CRC脑转移患者。荟萃分析结果显示，同时性和异时性BM患者的OS无显著差异（HR，0.90；95%置信区间，0.59 - 1.38；P = 0.63）。总之，该荟萃分析表明，BM发生时间对CRC脑转移患者的OS无影响。
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