Disease diversity and FLT3 mutations.
作者信息
Smith Catherine Choy
机构信息
Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, CA 94143.
出版信息
Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):20860-1. doi: 10.1073/pnas.1320579110. Epub 2013 Dec 9.
Abstract
摘要
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FLT3/D835Y mutation knock-in mice display less aggressive disease compared with FLT3/internal tandem duplication (ITD) mice.FLT3/D835Y 基因突变敲入小鼠与 FLT3/内部串联重复（ITD）小鼠相比，疾病侵袭性较弱。
Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):21113-8. doi: 10.1073/pnas.1310559110. Epub 2013 Nov 19.
2
Exome sequencing identifies recurring FLT3 N676K mutations in core-binding factor leukemia.外显子组测序鉴定核心结合因子白血病中复发性 FLT3 N676K 突变。
Blood. 2013 Sep 5;122(10):1761-9. doi: 10.1182/blood-2013-01-476473. Epub 2013 Jul 22.
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Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia.成人新发急性髓系白血病的基因组和表观基因组图谱。
N Engl J Med. 2013 May 30;368(22):2059-74. doi: 10.1056/NEJMoa1301689. Epub 2013 May 1.
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Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia.FLT3 内部串联重复突变在人类急性髓系白血病治疗靶点中的验证。
Nature. 2012 Apr 15;485(7397):260-3. doi: 10.1038/nature11016.
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A robust error model for iTRAQ quantification reveals divergent signaling between oncogenic FLT3 mutants in acute myeloid leukemia.一种稳健的 iTRAQ 定量误差模型揭示了急性髓系白血病中致癌性 FLT3 突变体之间不同的信号转导。
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