60例中国低级别胶质瘤患者中IDH1突变在肿瘤相关性癫痫中的意义
The significance of IDH1 mutations in tumor-associated seizure in 60 Chinese patients with low-grade gliomas.
作者信息
Liang Ruofei, Fan Yingjun, Wang Xiang, Mao Qing, Liu Yanhui
机构信息
Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu 610041, China.
出版信息
ScientificWorldJournal. 2013 Nov 13;2013:403942. doi: 10.1155/2013/403942. eCollection 2013.
BACKGROUND
Seizure is a common clinical presentation in patients suffering from primary brain tumors, especially from low-grade gliomas (LGGs). However, the genetic factors of tumor-associated seizure, at present, are still very poorly understood. The aim of this study was to investigate the potential correlation between tumor-associated epilepsy and IDH1 mutations in a Chinese population with LGGs.
MATERIALS AND METHODS
This study reviewed 60 patients with histologically confirmed low-grade gliomas, and the status of IDH1 was detected after the operation at our institution. Univariate and multivariate logistic regression analysis were used to explore the potential risk factors for tumor-related seizures. Results. IDH1 mutation was detected in 46 (76.7%) patients, among which 14 patients had no epilepsies and 32 patients had epilepsies (P = 0.023, chi-square test). Multivariate logistic regression analysis demonstrated that the mutation of IDH1 seems to be the strongest predictor for preoperative seizure (OR, 6.130; 95% CI, 1.523-24.669; P = 0.011).
CONCLUSIONS
IDH1 mutation was frequently detected in LGGs, and it may result in tumor-related seizures.
背景
癫痫发作是原发性脑肿瘤患者，尤其是低级别胶质瘤（LGG）患者常见的临床表现。然而，目前对肿瘤相关性癫痫发作的遗传因素仍知之甚少。本研究旨在探讨中国LGG患者中肿瘤相关性癫痫与异柠檬酸脱氢酶1（IDH1）突变之间的潜在相关性。
材料与方法
本研究回顾了60例经组织学确诊的低级别胶质瘤患者，并在我院术后检测了IDH1的状态。采用单因素和多因素逻辑回归分析来探讨肿瘤相关性癫痫发作的潜在危险因素。结果。46例（76.7%）患者检测到IDH1突变，其中14例无癫痫发作，32例有癫痫发作（P = 0.023，卡方检验）。多因素逻辑回归分析表明，IDH1突变似乎是术前癫痫发作的最强预测因素（比值比，6.130；95%可信区间，1.523 - 24.669；P = 0.011）。
结论
LGG中经常检测到IDH1突变，它可能导致肿瘤相关性癫痫发作。
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