Fujian Center for Disease Control and Prevention, Fujian, China.
National Center for Tuberculosis Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Tuberculosis (Edinb). 2014 Mar;94(2):159-61. doi: 10.1016/j.tube.2013.03.004. Epub 2013 Dec 8.
Of 75 MDR isolates from Fujian Province, the sensitivity of RIF, INH, EMB, SM, OFLX and KAN resistance by DNA sequencing was 96.0%, 96.0%, 66.7%, 66.0%, 84.2% and 75.0%, respectively. We also identified that minority mutations in the mixed Mycobacterium tuberculosis population may be responsible for two "false-negative" results. In addition, Beijing genotype is still the predominant sublineage in the MDR TB cases from Fujian.
在福建省的 75 株耐多药分离株中，通过 DNA 测序法检测利福平（RIF）、异烟肼（INH）、乙胺丁醇（EMB）、链霉素（SM）、氧氟沙星（OFLX）和卡那霉素（KAN）耐药的敏感性分别为 96.0%、96.0%、66.7%、66.0%、84.2%和 75.0%。我们还发现，混合结核分枝杆菌种群中的少数突变可能是导致两个“假阴性”结果的原因。此外，在福建省的耐多药结核病病例中，北京基因型仍然是主要的亚谱系。
