动力蛋白相关蛋白1（Drp1）的体内功能：从酵母遗传学和小鼠基因敲除中获得的经验教训
In vivo functions of Drp1: lessons learned from yeast genetics and mouse knockouts.
作者信息
Sesaki Hiromi, Adachi Yoshihiro, Kageyama Yusuke, Itoh Kie, Iijima Miho
机构信息
Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
出版信息
Biochim Biophys Acta. 2014 Aug;1842(8):1179-85. doi: 10.1016/j.bbadis.2013.11.024. Epub 2013 Dec 8.
Abstract
Mitochondria grow, divide, and fuse in cells. Mitochondrial division is critical for the maintenance of the structure and function of mitochondria. Alterations in this process have been linked to many human diseases, including peripheral neuropathies and aging-related neurological disorders. In this review, we discuss recent progress in mitochondrial division by focusing on molecular and in vivo analyses of the evolutionarily conserved, central component of mitochondrial division, dynamin-related protein 1 (Drp1), in the yeast and mouse model organisms.
摘要
线粒体在细胞中生长、分裂和融合。线粒体分裂对于维持线粒体的结构和功能至关重要。这一过程的改变与许多人类疾病相关，包括周围神经病变和衰老相关的神经障碍。在本综述中，我们通过聚焦酵母和小鼠模式生物中线粒体分裂的进化保守核心组分——动力相关蛋白1（Drp1）的分子和体内分析，来讨论线粒体分裂的最新进展。
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本文引用的文献
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The mitochondrial elongation factors MIEF1 and MIEF2 exert partially distinct functions in mitochondrial dynamics.线粒体延伸因子 MIEF1 和 MIEF2 在线粒体动力学中发挥部分不同的功能。
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Dynamics of nucleoid structure regulated by mitochondrial fission contributes to cristae reformation and release of cytochrome c.线粒体分裂调控核基质结构动力学有助于嵴重排和细胞色素 c 的释放。
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The scaffold protein Atg11 recruits fission machinery to drive selective mitochondria degradation by autophagy.支架蛋白 Atg11 招募分裂机制，通过自噬驱动选择性线粒体降解。
Dev Cell. 2013 Jul 15;26(1):9-18. doi: 10.1016/j.devcel.2013.05.024. Epub 2013 Jun 27.
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Cyclin-dependent kinases regulate splice-specific targeting of dynamin-related protein 1 to microtubules.周期蛋白依赖性激酶调节动力相关蛋白 1 剪接特异性靶向微管。
J Cell Biol. 2013 Jun 24;201(7):1037-51. doi: 10.1083/jcb.201210045.
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ER-associated mitochondrial division links the distribution of mitochondria and mitochondrial DNA in yeast.内质网相关的线粒体分裂与酵母中线粒体及线粒体DNA的分布相关。
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The yeast cell cortical protein Num1 integrates mitochondrial dynamics into cellular architecture.酵母细胞皮质蛋白 Num1 将线粒体动力学整合到细胞结构中。
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