Sesaki Hiromi, Adachi Yoshihiro, Kageyama Yusuke, Itoh Kie, Iijima Miho
Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Biochim Biophys Acta. 2014 Aug;1842(8):1179-85. doi: 10.1016/j.bbadis.2013.11.024. Epub 2013 Dec 8.
Mitochondria grow, divide, and fuse in cells. Mitochondrial division is critical for the maintenance of the structure and function of mitochondria. Alterations in this process have been linked to many human diseases, including peripheral neuropathies and aging-related neurological disorders. In this review, we discuss recent progress in mitochondrial division by focusing on molecular and in vivo analyses of the evolutionarily conserved, central component of mitochondrial division, dynamin-related protein 1 (Drp1), in the yeast and mouse model organisms.
线粒体在细胞中生长、分裂和融合。线粒体分裂对于维持线粒体的结构和功能至关重要。这一过程的改变与许多人类疾病相关，包括周围神经病变和衰老相关的神经障碍。在本综述中，我们通过聚焦酵母和小鼠模式生物中线粒体分裂的进化保守核心组分——动力相关蛋白1（Drp1）的分子和体内分析，来讨论线粒体分裂的最新进展。
