Wang Nan, Wang Xinwai, Lan Beiwu, Gao Yufei, Cai Yuanyuan
The Department of Neurosurgery, China-Japan Union Hospital of Jilin University, Changchun, China.
The First Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, China.
Cell Death Discov. 2025 Apr 7;11(1):150. doi: 10.1038/s41420-025-02458-0.
Mitochondrial fission is a critical physiological process in eukaryotic cells, participating in various vital activities such as mitosis, mitochondria quality control, and mitophagy. Recent studies have revealed a tight connection between mitochondrial fission and the mitochondrial metabolism, as well as apoptosis, which involves multiple cellular events and interactions between organelles. As a pivotal molecule in the process of mitochondrial fission, the function of DRP1 is regulated at multiple levels, including transcription, post-translational modifications. This review follows the guidelines for Human Gene Nomenclature and will focus on DRP1, discussing its activity regulation, its role in mitochondrial fission, and the relationship between mitochondrial fission and apoptosis.
线粒体分裂是真核细胞中的一个关键生理过程，参与有丝分裂、线粒体质量控制和线粒体自噬等各种重要活动。最近的研究揭示了线粒体分裂与线粒体代谢以及细胞凋亡之间的紧密联系，细胞凋亡涉及多个细胞事件和细胞器之间的相互作用。作为线粒体分裂过程中的一个关键分子，动力相关蛋白1（DRP1）的功能在多个水平受到调控，包括转录、翻译后修饰。本综述遵循人类基因命名法指南，将聚焦于DRP1，讨论其活性调节、在 mitochondrial fission 中的作用以及线粒体分裂与细胞凋亡之间的关系。
