Savelieff Masha G, Liu Yuzhong, Senthamarai Russell R P, Korshavn Kyle J, Lee Hyuck Jin, Ramamoorthy Ayyalusamy, Lim Mi Hee
Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Chem Commun (Camb). 2014 May 25;50(40):5301-3. doi: 10.1039/c3cc48473d. Epub 2013 Dec 10.
Alzheimer's disease (AD) is a complex, multifactorial, neurodegenerative disease that poses tremendous difficulties in pinpointing its precise etiology. A toolkit, which specifically targets and modulates suggested key players, may elucidate their roles in disease onset and progression. We report high-resolution insights on the activity of a small molecule (L2-NO) which exhibits reactivity toward Cu(II)-amyloid-β (Aβ) over Zn(II)-Aβ.
阿尔茨海默病（AD）是一种复杂的、多因素的神经退行性疾病，在确定其确切病因方面存在巨大困难。一种专门针对并调节所提出的关键因素的工具包，可能会阐明它们在疾病发生和发展中的作用。我们报告了对一种小分子（L2-NO）活性的高分辨率见解，该小分子对铜（II）-淀粉样β蛋白（Aβ）的反应性高于锌（II）-Aβ。
