Bagheri Soghra, Squitti Rosanna, Haertlé Thomas, Siotto Mariacristina, Saboury Ali A
Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio-Fatebenefratelli, Brescia, Italy.
Front Aging Neurosci. 2018 Jan 23;9:446. doi: 10.3389/fnagi.2017.00446. eCollection 2017.
Alzheimer's disease (AD) is a neurodegenerative disorder that is characterized by amyloid plaques in patients' brain tissue. The plaques are mainly made of β-amyloid peptides and trace elements including Zn, Cu, and Fe. Some studies have shown that AD can be considered a type of metal dyshomeostasis. Among metal ions involved in plaques, numerous studies have focused on copper ions, which seem to be one of the main cationic elements in plaque formation. The involvement of copper in AD is controversial, as some studies show a copper deficiency in AD, and consequently a need to enhance copper levels, while other data point to copper overload and therefore a need to reduce copper levels. In this paper, the role of copper ions in AD and some contradictory reports are reviewed and discussed.
阿尔茨海默病（AD）是一种神经退行性疾病，其特征是患者脑组织中出现淀粉样斑块。这些斑块主要由β-淀粉样肽以及包括锌、铜和铁在内的微量元素组成。一些研究表明，AD可被视为一种金属稳态失衡类型。在参与斑块形成的金属离子中，众多研究聚焦于铜离子，铜离子似乎是斑块形成中的主要阳离子元素之一。铜在AD中的作用存在争议，因为一些研究表明AD患者存在铜缺乏，因此需要提高铜水平，而其他数据则指出铜过载，所以需要降低铜水平。本文对铜离子在AD中的作用以及一些相互矛盾的报道进行了综述和讨论。
