Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, ETH Zurich, 8093 Zurich, Switzerland.
Chem Commun (Camb). 2014 Feb 7;50(10):1195-7. doi: 10.1039/c3cc48486f.
A novel approach towards the asymmetric synthesis of N-stereogenic molecules via double aza-Michael addition was developed. The diastereomeric ratio can be increased by a thermodynamically controlled isomerization mechanism. Simple separation and functionalization of the products afford N-stereogenic compounds in high enantiomeric purity.
发展了一种通过双氮杂迈克尔加成不对称合成 N-手性分子的新方法。通过热力学控制的异构化机制可以提高非对映选择性比。通过简单的分离和产物官能化，可以得到高对映体纯度的 N-手性化合物。
