1Department of Epidemiology, La Rioja Regional Authority, Logroño, Spain.
Lupus. 2014 Apr;23(4):431-5. doi: 10.1177/0961203313517015. Epub 2013 Dec 10.
Incidence and mortality of systemic lupus erythematosus (SLE) seem to be increasing in the last few decades, in contrast to the survival rate that has improved over time. The objective of this study was to examine the trends in the SLE mortality in Spain over a 30-year period (1981-2010).
Data on SLE deaths were drawn from the National Statistics Institute of Spain. Crude and overall age-standardized SLE mortality rates were calculated and joinpoint regression models were used to describe trend changes. Mean age of deaths by SLE each year was also assessed.
The overall age-standardized SLE mortality rate was 1.82 per million in 1981 and 2.24 in 2010. It was higher in women, 1.39 vs 0.43 in 1981 and 1.96 vs 0.28 in 2010. There was a statistically significant change in 1999. The overall age-standardized mortality rate increased from 1981 to 1999 and stabilized from 2000 to 2010. Only male rates decreased from 2000 to 2010. The mean age at death increased with time, from 42 years in 1981 to 61 years in 2010.
In conclusion, a slight decrease in SLE mortality has been observed in Spain over the last decade and future studies would be needed to explain the factors contributing to the improvement in the mortality rates.
在过去几十年中，红斑狼疮（SLE）的发病率和死亡率似乎有所增加，而存活率却随着时间的推移而提高。本研究旨在探讨西班牙 30 年来（1981-2010 年）SLE 死亡率的趋势。
从西班牙国家统计局获取 SLE 死亡数据。计算了粗死亡率和总体年龄标准化死亡率，并使用连接点回归模型描述趋势变化。还评估了每年 SLE 死亡的平均年龄。
1981 年的总体年龄标准化 SLE 死亡率为每百万 1.82，2010 年为每百万 2.24。女性的死亡率更高，1981 年为 1.39，2010 年为 0.43，1981 年为 1.96，2010 年为 0.28。1999 年发生了统计学意义上的变化。1981 年至 1999 年，总体年龄标准化死亡率增加，2000 年至 2010 年趋于稳定。只有男性的死亡率从 2000 年到 2010 年有所下降。死亡时的平均年龄随着时间的推移而增加，从 1981 年的 42 岁增加到 2010 年的 61 岁。
总之，西班牙过去十年中 SLE 死亡率略有下降，需要进一步研究来解释导致死亡率改善的因素。
