Elder James T
Department of Dermatology, University of Michigan Medical School and Ann Arbor VA Hospital, Ann Arbor, Michigan, USA.
J Investig Dermatol Symp Proc. 2013 Dec;16(1):S34-6. doi: 10.1038/jidsymp.2013.10.
Previous genetic epidemiological studies of psoriasis and alopecia areata demonstrated strong heritability in first-degree relatives and in twins. In recent years, these two conditions have emerged as two skin diseases that are starting to yield their secrets through genome-wide association studies. Both diseases manifest prominent human leukocyte antigen (HLA) associations, psoriasis primarily with major histocompatibility complex (MHC) Class 1, specifically HLA-Cw6, and alopecia areata primarily with MHC Class II. Despite these differences in HLA associations, both diseases have in common a prominent role for CD8+ lymphocytes. The purpose of this brief review is to present the recent developments in the genetics of psoriasis.
先前关于银屑病和斑秃的遗传流行病学研究表明，这两种疾病在一级亲属和双胞胎中具有很强的遗传性。近年来，这两种疾病已成为两种皮肤病，通过全基因组关联研究开始揭示其奥秘。这两种疾病均表现出显著的人类白细胞抗原（HLA）相关性，银屑病主要与主要组织相容性复合体（MHC）I类相关，特别是HLA-Cw6，而斑秃主要与MHC II类相关。尽管在HLA相关性方面存在这些差异，但这两种疾病的CD8 +淋巴细胞均发挥着重要作用。本简要综述的目的是介绍银屑病遗传学的最新进展。
