Milder multiple sclerosis course in patients with concomitant inflammatory bowel disease.
作者信息
Zéphir Hélène, Gower-Rousseau Corinne, Salleron Julia, Simon Olivier, Debouverie Marc, Le Page Emmanuelle, Bouhnik Yoram, Lebrun-Frenay Christine, Papeix Caroline, Vigneron Benoît, Allez Matthieu, Prin Lionel, Cosnes Jacques, Vermersch Patrick, Colombel Jean-Frédéric
机构信息
Department of Neurology, Hôpital Roger Salengro, France Department of Immunology, University of Lille Nord de France, France
Epidemiology Unit, Lille Hospital, France.
出版信息
Mult Scler. 2014 Jul;20(8):1135-9. doi: 10.1177/1352458513515081. Epub 2013 Dec 10.
An association between multiple sclerosis (MS) and inflammatory bowel disease (IBD) has been suggested. The purpose of this study was to compare the disease course of patients with both MS and IBD with that of patients with isolated MS or isolated IBD. Sixty-six MS-IBD patients were identified and were matched with 251 isolated MS and 257 isolated IBD controls. Main outcomes were scores using the Expanded Disability Status Scale (EDSS) in MS and extent of disease extension in IBD at last clinical evaluation. After a median 12 years of disease duration, the median EDSS and the percentages of patients reaching an EDSS of 3.0 and 4.0 were significantly lower in MS-IBD patients than in controls. MS had no impact on IBD. MS course appears to be milder in patients with concomitant IBD.
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