Koutroubakis Ioannis E, Drygiannakis Dimitrios, Karmiris Konstantinos, Drygiannakis Ioannis, Makreas Sokratis, Kouroumalis Elias A
Department of Gastroenterology, University Hospital, Heraklion, Greece.
Dig Dis Sci. 2005 Dec;50(12):2330-4. doi: 10.1007/s10620-005-3056-0.
Pancreatic autoantibodies (PAbs) have been suggested as a specific but not sensitive marker for Crohn's disease (CD). The aim of this study was to assess the value of detecting PAbs in Greek patients with ulcerative colitis (UC) and CD. Sera were collected from 150 patients with IBD (73 with UC and 77 with CD), 31 cases with non-IBD intestinal inflammation, 16 cases with other autoimmune diseases, and 104 healthy controls. Determination of PAbs was performed by a standard indirect immunofluorescence technique. PAbs were detected in 18 of 73 (24.7%) samples from UC patients and in 32 of 77 (41.6%) samples from CD patients. The prevalence of positive PAbs was significantly higher in CD than in UC (P = 0.04). None of the 104 samples from healthy controls and the 31 cases with non-IBD intestinal inflammation had detectable PAbs. One patient with Sjogren's syndrome was PAbs positive. No association of PAbs with IBD activity, IBD localization, or medical treatment was found. Patients with stenotic CD had a significantly higher prevalence of PAbs positivity (60%) compared with patients with inflammatory (28.6%) and fistulizing (41.2%) disease (P = 0.02). The prevalence of PAbs in Greek CD patients was found to be similar to that in previous reports. In contrast to these studies we found also increased prevalence of PAbs in UC patients. These findings suggest that PAbs should be considered as a specific marker for IBD rather than for CD.
胰腺自身抗体（PAbs）被认为是克罗恩病（CD）的一种特异性但不敏感的标志物。本研究的目的是评估检测希腊溃疡性结肠炎（UC）和CD患者中PAbs的价值。收集了150例炎症性肠病（IBD）患者（73例UC患者和77例CD患者）、31例非IBD肠道炎症患者、16例其他自身免疫性疾病患者以及104例健康对照者的血清。采用标准间接免疫荧光技术测定PAbs。在73例UC患者的18份样本（24.7%）和77例CD患者的32份样本（41.6%）中检测到PAbs。CD患者中PAbs阳性率显著高于UC患者（P = 0.04）。104例健康对照者和31例非IBD肠道炎症患者的样本中均未检测到可检测到的PAbs。1例干燥综合征患者PAbs呈阳性。未发现PAbs与IBD活动度、IBD定位或药物治疗之间存在关联。与炎症性（28.6%）和瘘管性（41.2%）疾病患者相比，狭窄性CD患者的PAbs阳性率显著更高（60%）（P = 0.02）。希腊CD患者中PAbs的患病率与先前报道相似。与这些研究不同的是，我们还发现UC患者中PAbs的患病率也有所增加。这些发现表明，PAbs应被视为IBD而非CD的特异性标志物。
