Jiang Ping, Cui Su-Ping, Ren Ya-Li, Mao Jing-Zhuo, Liu Hai-Jing, Tian Yuan, Liu Jian-Ying, Du Juan, Hou Lin, Zhang Bo
Tumori. 2013 Jul-Aug;99(4):530-4. doi: 10.1177/030089161309900415.
Increasing evidence claims that autophagy is essential for breast cancer progression. Girdin was found highly expressed in breast cancers. It has been reported that Girdin attenuates autophagy in HeLa cells. We explored the relationship between Girdin expression and autophagic patterns in breast cancer.
In the study, Girdin expression and autophagic activity were investigated in a series of 99 invasive ductal breast carcinomas after immunohistochemical staining for the autophagy-associated proteins LC3-II and Girdin.
The level of Girdin expression negatively correlated with LC3-II level, which represents autophagic activity (r = -0.289), and positively correlated with lymph node metastasis (r = 0.472). Girdin level was found no different in the "diffuse cytoplasmic" and "stone-like" patterns of LC3-II.
Up-regulated autophagy was negatively associated with Girdin level. There was a significant correlation between Girdin expression and lymph nodes metastasis in invasive ductal breast carcinoma.
越来越多的证据表明自噬对乳腺癌进展至关重要。已发现Girdin在乳腺癌中高表达。据报道，Girdin可减弱HeLa细胞中的自噬。我们探讨了乳腺癌中Girdin表达与自噬模式之间的关系。
在本研究中，对99例浸润性导管癌进行免疫组化染色，检测自噬相关蛋白LC3-II和Girdin，以研究Girdin表达和自噬活性。
Girdin表达水平与代表自噬活性的LC3-II水平呈负相关（r = -0.289），与淋巴结转移呈正相关（r = 0.472）。在LC3-II的“弥漫性细胞质”和“石样”模式中，Girdin水平无差异。
自噬上调与Girdin水平呈负相关。浸润性导管癌中Girdin表达与淋巴结转移之间存在显著相关性。
