Department of Breast Surgery, General Surgery, The First Affiliated Hospital of China Medical University, Shenyang, 110001 Liaoning Province, China.
Med Oncol. 2012 Sep;29(3):1554-60. doi: 10.1007/s12032-011-0087-6. Epub 2011 Nov 25.
To investigate the expression status and the clinical implications of Girdin protein in breast cancer. The expression status of Girdin protein and clinicopathological parameters in 820 breast cancer specimens was analyzed using immunohistochemistry staining and the relationship between Girdin protein and clinicopathological parameters. The prognosis of breast cancer was subsequently determined. Girdin protein was expressed positively in 295 (35.98%) of the 820 cases examined. The expression of Girdin protein was related to histological type and CerbB2 (P = 0.001, 0.006, and 0.001, respectively). After analyzing survival rates, the cases with highly expressed Girdin protein were shown to attain a significantly more distant metastasis rate and poorer postoperative, disease-specific survival than those with none or low expressed Girdin protein (P = 0.001). In the Cox regression test, Girdin protein was detected as an independent prognostic factor (P = 0.031). Girdin protein may be a potential new distant metastasis biomarker of breast cancer.
为了研究 Girdin 蛋白在乳腺癌中的表达状态及其临床意义。采用免疫组织化学染色法分析 820 例乳腺癌标本中 Girdin 蛋白的表达状态及其与临床病理参数的关系，进而确定乳腺癌的预后。820 例检测中，有 295 例（35.98%）Girdin 蛋白呈阳性表达。Girdin 蛋白的表达与组织学类型和 CerbB2 相关（P = 0.001、0.006 和 0.001）。对生存率进行分析后，结果显示高表达 Girdin 蛋白的病例远处转移率更高，术后无病生存率和疾病特异性生存率更差，而无表达或低表达 Girdin 蛋白的病例则不然（P = 0.001）。在 Cox 回归检验中，Girdin 蛋白被检测为独立的预后因素（P = 0.031）。Girdin 蛋白可能是乳腺癌潜在的新的远处转移生物标志物。
