Department of Biotechnology & Medical Engineering, National Institute of Technology, Rourkela, 769008, Odisha, India,
J Mater Sci Mater Med. 2014 Mar;25(3):703-21. doi: 10.1007/s10856-013-5112-1. Epub 2013 Dec 11.
Gels have been considered as a popular mode of delivering medicament for the treatment of sexually transmitted diseases (STDs) (e.g. human immunodeficiency virus, bacterial vaginosis, epididymitis, human papillomavirus infection and condylomata acuminata etc.). The present study discusses the development of novel olive oil based emulsion hydrogels (EHs) using sorbitan monopalmitate as the structuring agent. The developed EHs may be tried as drug delivery vehicle for the treatment of STDs. The formation of EHs was confirmed by fluorescence and confocal microscopy. FTIR studies suggested intermolecular hydrogen bonding amongst the components of the EHs. X-ray diffraction study suggested the amorphous nature of the EHs. The developed EHs have shown non-Newtonian flow behavior. The EHs were found to be biocompatible. The formulations were able to effectively deliver two model antimicrobial drugs (e.g. ciprofloxacin and metronidazole), commonly used in the treatment of the STDs.
凝胶已被认为是一种用于治疗性传播疾病（例如人类免疫缺陷病毒、细菌性阴道病、附睾炎、人乳头瘤病毒感染和尖锐湿疣等）的药物的流行给药方式。本研究讨论了使用山梨醇单棕榈酸酯作为结构剂开发新型橄榄油基乳液水凝胶（EHs）。所开发的 EHs 可作为治疗性传播疾病的药物递送载体进行尝试。通过荧光和共焦显微镜证实了 EHs 的形成。FTIR 研究表明 EHs 中的成分之间存在分子间氢键。X 射线衍射研究表明 EHs 具有无定形性质。所开发的 EHs 表现出非牛顿流动行为。EHs 被发现具有生物相容性。这些配方能够有效地递送电镜下可见的两种模型抗菌药物（例如，常用于治疗性传播疾病的环丙沙星和甲硝唑）。
