白细胞介素10基因-592C/A多态性与冠状动脉疾病的关联
[Association of interleukin 10 gene -592C/A polymorphism with coronary artery disease].
作者信息
Jin Hu, Wang Yan, Xu Li-xing
机构信息
Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang 325027, P.R. China.
出版信息
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2013 Dec;30(6):724-8. doi: 10.3760/cma.j.issn.1003-9406.2013.06.020.
OBJECTIVE
To assess the association of interleukin 10 (IL10) gene -592C/A polymorphism with morbidity of coronary heart disease in a southern Chinese Han population.
METHODS
Frequencies of various genotypes and alleles for the IL10 -592C/A polymorphism (rs1800872) were determined by the means of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) in 249 patients and 132 unaffected controls.
RESULTS
The frequencies of both IL10 -592C/A site and different alleles have reached statistical significance (P<0.05) after correcting the difference in clinical data by logistic regression analysis. The risk of coronary heart disease in the patients with A gene (AA+CA) was 2.449 times greater than those without (95%CI:1.214-4.940, P=0.012).
CONCLUSION
IL10 gene -592C/A polymorphism is associated with the risk of coronary heart disease. Allele A may be a risk factor for this disease in the studied population.
目的
评估白细胞介素10（IL10）基因-592C/A多态性与中国南方汉族人群冠心病发病的相关性。
方法
采用基质辅助激光解吸/电离飞行时间质谱法（MALDI-TOF-MS）测定249例患者和132例未受影响对照者中IL10 -592C/A多态性（rs1800872）的各种基因型和等位基因频率。
结果
经逻辑回归分析校正临床数据差异后，IL10 -592C/A位点及不同等位基因频率均具有统计学意义（P<0.05）。携带A基因（AA+CA）的患者患冠心病的风险是未携带者的2.449倍（95%CI：1.214-4.940，P=0.012）。
结论
IL10基因-592C/A多态性与冠心病风险相关。在研究人群中，等位基因A可能是该疾病的一个危险因素。
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