Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Biochem Genet. 2021 Oct;59(5):1089-1115. doi: 10.1007/s10528-021-10056-9. Epub 2021 Mar 23.
Several studies have previously assessed the association between interleukin (IL)-10 gene polymorphisms and the risk of asthma, leading to conflicting results. To resolve the incongruent outcomes yielded from different single studies, we conducted the most up-to-date meta-analysis of the IL-10 gene rs1800896, rs1800871, and rs1800872 single-nucleotide polymorphisms (SNPs) and susceptibility to asthma. A systematic literature search performed until April 2020, and the pooled odds ratio (OR) and their corresponding 95% confidence interval (CI) were calculated to determine the association strength. Thirty articles comprising 5678 asthmatic patients and 6079 controls met the inclusion criteria. No significant association was found between rs1800872 SNP and susceptibility to asthma across all genetic models in the overall and subgroup analyses. The rs1800871 SNP had only significant association with a decreased risk of asthma in Europeans (OR 0.66, CI 0.53-0.82, P < 0.001). However, rs1800896 SNP was significantly associated with a decreased risk of asthma by dominant (OR 0.67, CI 0.50-0.90, P < 0.001) and heterozygote (OR 0.66, CI 0.49-0.88, P < 0.001) models in the overall analysis. Subgroup analyses indicated significant association of rs1800896 SNP by dominant (OR 0.45, CI 0.28-0.72, P < 0.001) and heterozygote (OR 0.43, CI 0.26-0.70, P < 0.001) models in the African population. The IL-10 rs1800896 SNP confers protection against the risk of asthma, especially in Africans. Additionally, rs1800871 SNP has a protective role against asthma in Europeans.
先前有几项研究评估了白细胞介素 (IL)-10 基因多态性与哮喘风险之间的关联，但其结果存在冲突。为了解决不同单中心研究结果不一致的问题，我们对 IL-10 基因 rs1800896、rs1800871 和 rs1800872 单核苷酸多态性 (SNP) 与哮喘易感性的关系进行了最新的荟萃分析。系统文献检索截至 2020 年 4 月，计算汇总优势比 (OR) 及其相应的 95%置信区间 (CI)，以确定关联强度。符合纳入标准的 30 篇文章包括 5678 例哮喘患者和 6079 例对照。在所有遗传模型的总体和亚组分析中，rs1800872 SNP 与哮喘易感性之间均无显著关联。rs1800871 SNP 仅在欧洲人群中与哮喘风险降低显著相关 (OR 0.66，CI 0.53-0.82，P<0.001)。然而，rs1800896 SNP 与哮喘风险降低显著相关，显性模型 (OR 0.67，CI 0.50-0.90，P<0.001) 和杂合子模型 (OR 0.66，CI 0.49-0.88，P<0.001)。亚组分析表明，rs1800896 SNP 在显性模型 (OR 0.45，CI 0.28-0.72，P<0.001) 和杂合子模型 (OR 0.43，CI 0.26-0.70，P<0.001) 中与非洲人群显著相关。IL-10 rs1800896 SNP 可降低哮喘风险，尤其在非洲人群中。此外，rs1800871 SNP 对欧洲人群的哮喘具有保护作用。
