Ramoth T, Hovakimyan M, Guthoff R F, Stachs O
Augenklinik, Universität Rostock.
Klin Monbl Augenheilkd. 2013 Dec;230(12):1220-4. doi: 10.1055/s-0033-1351069. Epub 2013 Dec 10.
The implementation of additional modalities for tear film break-up time characterisation expands the application range of the Oculus® Keratograph 5M. The aim of the present study was to evaluate the possibilities for non-invasive break-up time analysis using this device. Furthermore we applied the Oculus® Keratograph 5M to characterise possible modifications of tear break-up time after application of Thealoz® eye drops (Théa Pharma). The device allowed for a precise and solid topographical analysis of tear film dynamics. We could show that at four weeks after treatment, trehalose solution was a better treatment for dry eye compared with saline. These results are in agreement with our previous in vitro findings concerning the protective role of trehalose on desiccation-caused cell death in a corneal epithelial model.
泪膜破裂时间表征附加模式的实施扩大了Oculus® Keratograph 5M的应用范围。本研究的目的是评估使用该设备进行无创破裂时间分析的可能性。此外，我们应用Oculus® Keratograph 5M来表征使用Thealoz®滴眼液（泰阿制药）后泪膜破裂时间的可能变化。该设备能够对泪膜动力学进行精确而可靠的地形图分析。我们可以证明，治疗四周后，与生理盐水相比，海藻糖溶液对干眼症的治疗效果更好。这些结果与我们之前在角膜上皮模型中海藻糖对干燥引起的细胞死亡的保护作用的体外研究结果一致。
