Levenbook I S, Elisberg B L, Driscoll B F
Vaccine. 1986 Dec;4(4):225-7. doi: 10.1016/0264-410x(86)90133-7.
Rabies vaccine produced in rhesus diploid cells (RDRV) and adsorbed on aluminium phosphate was evaluated for its neurological safety in guinea pigs and Lewis rats. The vaccine (as well as aluminium phosphate itself) in combination with myelin basic protein did not induce experimental allergic encephalomyelitis (EAE) when injected into either species. RDRV combined with complete Freund's adjuvant still failed to induce any signs of EAE. In contrast, basic protein combined with complete Freund's adjuvant induced severe EAE in both guinea pigs and rats. No experimental evidence was obtained to indicate adverse neuroimmunological activity of RDRV.
对用恒河猴二倍体细胞生产并吸附于磷酸铝的狂犬病疫苗（RDRV）在豚鼠和Lewis大鼠中进行了神经安全性评估。该疫苗（以及磷酸铝本身）与髓鞘碱性蛋白联合注射到这两种动物中时，均未诱发实验性过敏性脑脊髓炎（EAE）。RDRV与完全弗氏佐剂联合使用仍未能诱发任何EAE迹象。相比之下，碱性蛋白与完全弗氏佐剂联合使用在豚鼠和大鼠中均诱发了严重的EAE。未获得实验证据表明RDRV具有不良的神经免疫活性。
