Englert D, Hempel K
Int Arch Allergy Appl Immunol. 1981;66(3):326-31. doi: 10.1159/000232837.
Experimental allergic encephalomyelitis (EAE) in Lewis rats was suppressed by pretreatment with complete Freund's adjuvant (CFA) 14-16 days before immunization with basic protein (BP) in CFA. Suppression of active EAE was also accomplished clinically and even histologically if lymph node cells from CFA-treated donors were passively transferred. Obviously this depends first on a certain amount of transferred lymph node cells (about 3 X 108) and secondly on the interval between CFA application and cell harvest (more than 14 days). No suppression was obtained by transfer of serum from CFA-treated donors. This indicates that there is a suppressor cell population which can be raised or stimulated by CFA and which is capable of suppressing the immune response EAE.
在Lewis大鼠中，实验性变应性脑脊髓炎（EAE）在用含碱性蛋白（BP）的完全弗氏佐剂（CFA）免疫前14 - 16天，通过CFA预处理得以抑制。如果将来自经CFA处理的供体的淋巴结细胞进行被动转移，在临床甚至组织学上也能实现对活动性EAE的抑制。显然，这首先取决于一定数量的转移淋巴结细胞（约3×10⁸），其次取决于应用CFA与收获细胞之间的间隔（超过14天）。经CFA处理的供体血清转移未获得抑制效果。这表明存在一种抑制性细胞群体，它可被CFA激活或刺激，并且能够抑制EAE的免疫反应。
