禽逆转录病毒包膜亚组特异性的区域编码并不决定淋巴瘤发生能力。
Region coding for subgroup specificity of envelope of avian retroviruses does not determine lymphomagenicity.
作者信息
Wright S E, Bennett D D
出版信息
Virus Res. 1986 Nov;6(2):173-80. doi: 10.1016/0168-1702(86)90048-1.
The purpose of this study was to test whether the region coding for subgroup envelope specificity was a determinant of oncogenic potential. An avian retrovirus recombinant was constructed to contain the envelope gene (env) determinant for subgroup A of an avian RNA tumor virus in one of the non-oncogenic, endogenous avian retroviruses, RAV-0. The results show that such a recombinant virus does not induce lymphoma when injected into susceptible, newborn chicks. Thus, it is concluded that the envelope determinant for subgroup of avian RNA tumor viruses does not determine malignant potential.
本研究的目的是测试编码亚组包膜特异性的区域是否是致癌潜力的决定因素。构建了一种禽逆转录病毒重组体，使其在一种非致癌的内源性禽逆转录病毒RAV-0中包含禽RNA肿瘤病毒A亚组的包膜基因（env）决定簇。结果表明，将这种重组病毒注射到易感的新生雏鸡中不会诱发淋巴瘤。因此，可以得出结论，禽RNA肿瘤病毒亚组的包膜决定簇不能决定恶性潜能。
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