病毒基因组的至少两个区域决定了禽白血病病毒的致癌潜力。
At least two regions of the viral genome determine the oncogenic potential of avian leukosis viruses.
作者信息
Robinson H L, Blais B M, Tsichlis P N, Coffin J M
出版信息
Proc Natl Acad Sci U S A. 1982 Feb;79(4):1225-9. doi: 10.1073/pnas.79.4.1225.
Abstract
Recombinants of oncogenic and nononcogenic avian leukosis viruses were tested for their oncogenic potential in chickens. The results indicate that at least two regions of the viral genome determine the oncogenic potential of these viruses. The first region contains sequences that control viral mRNA synthesis. These sequences determine the potential of a virus to induce a low incidence of lymphomas, carcinomas, chondrosarcomas, fibrosarcomas, and osteopetrosis. The second region lies outside the sequences that control viral mRNAs synthesis. These sequences determine the ability of a virus to induce a high incidence of lymphomas or osteopetrosis.
摘要
对致癌性和非致癌性禽白血病病毒的重组体进行了鸡的致癌潜力测试。结果表明，病毒基因组的至少两个区域决定了这些病毒的致癌潜力。第一个区域包含控制病毒mRNA合成的序列。这些序列决定了病毒诱导淋巴瘤、癌、软骨肉瘤、纤维肉瘤和骨质石化低发生率的可能性。第二个区域位于控制病毒mRNA合成的序列之外。这些序列决定了病毒诱导淋巴瘤或骨质石化高发生率的能力。
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