Life Sciences, Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, VA, USA.
Chem Biodivers. 2013 Dec;10(12):2221-5. doi: 10.1002/cbdv.201300214.
We extend recent modeling studies of proton hopping, used to describe the functioning of membrane channels and axon nerve conduction, to offer an explanation of the initiation of the nerve impulse at an effector-ligand encounter. This encounter is proposed to create a hydronium ion in the vicinity of the effector and ligand, which leads to a continuous flow of protons, called proton hopping, through water adjacent to this encounter. This proton hopping is proposed to be the message carried from the encounter to the axon of a particular nerve system associated with that particular effector-ligand system.
我们将最近的质子跳跃建模研究扩展到解释神经冲动的起始，该研究用于描述膜通道和轴突神经传导的功能。我们提出，在效应器-配体相互作用处附近形成一个氢离子，导致质子通过与该相互作用相邻的水分子连续跳跃，从而产生连续的质子跳跃。我们提出，这种质子跳跃是从相互作用处传递到与该特定效应器-配体系统相关的特定神经系统的轴突的信息。
