Li Yan, Lu Jiapeng, Wu Xiaogang, Yang Chunlei
Department of Epidemiology, Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China
Department of Epidemiology, Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China.
Angiology. 2014 Aug;65(7):634-40. doi: 10.1177/0003319713513143. Epub 2013 Dec 9.
We assessed the effect of increased serum uric acid (SUA) concentration and hyperuricemia on subclinical organ damage. A cross-sectional examination of 1243 asymptomatic patients aged 55 to 84 years was conducted from September to October 2012. All participants underwent the measurements of SUA and other established cardiovascular (CV) risk factors. A morning spot urine sample was collected to detect microalbuminuria, and carotid plaque was scanned by B-mode ultrasound; the cardioankle vascular index and ankle-brachial index were obtained to evaluate arterial stiffness and peripheral artery disease (PAD), respectively. After adjustment for established CV risk factors, multiple logistic regression analyses showed that the highest quartile of SUA concentration and hyperuricemia had an independent association with PAD (respective odds ratios: 3.86 [1.26-11.83] and 2.33 [1.14-4.77]); this association maintained significantly in males but disappeared in females. Serum uric acid concentration and hyperuricemia are significantly associated with PAD in males.
我们评估了血清尿酸（SUA）浓度升高及高尿酸血症对亚临床器官损害的影响。2012年9月至10月，对1243例年龄在55至84岁的无症状患者进行了横断面检查。所有参与者均接受了SUA及其他既定心血管（CV）危险因素的测量。收集晨尿样本以检测微量白蛋白尿，并用B型超声扫描颈动脉斑块；分别获取心踝血管指数和踝臂指数以评估动脉僵硬度和外周动脉疾病（PAD）。在对既定的CV危险因素进行校正后，多因素logistic回归分析显示，SUA浓度最高四分位数及高尿酸血症与PAD独立相关（各自的比值比：3.86 [1.26 - 11.83]和2.33 [1.14 - 4.77]）；这种关联在男性中显著存在，但在女性中消失。血清尿酸浓度及高尿酸血症在男性中与PAD显著相关。
