Wahl R L, Khazaeli M B, LoBuglio A F, Patillo R A, Tuscan M J, Beierwaltes W H
Am J Obstet Gynecol. 1987 Jan;156(1):108-11. doi: 10.1016/0002-9378(87)90216-x.
Localized recurrent gestational choriocarcinoma, evidenced by a rising level of the beta-subunit of human chorionic gonadotropin, can be difficult to localize for surgical resection. We describe a patient with a rising level of the beta-subunit of human chorionic gonadotropin after extensive therapy for choriocarcinoma in which gamma scanning of the distribution of an intravenously administered iodine 131-labeled monoclonal antibody preparation (5F9.3) allowed localization of a focus of recurrent choriocarcinoma in the lung. Other imaging methods showed this only as a focus of stable scarring. The antibody scan guided surgical resection of this tumor focus, which on gamma counting had a tenfold excess of antibody activity compared with that of the normal lung. This approach may be useful in detecting occult foci of gestational choriocarcinoma for surgical resection in patients with rising levels of the beta-subunit of human chorionic gonadotropin and is under further evaluation.
人绒毛膜促性腺激素β亚基水平升高提示的局限性复发性妊娠滋养细胞肿瘤，可能难以定位以便进行手术切除。我们描述了一名患者，其在接受绒毛膜癌广泛治疗后人绒毛膜促性腺激素β亚基水平升高，通过静脉注射碘131标记的单克隆抗体制剂（5F9.3）分布的γ扫描，确定了肺部复发性绒毛膜癌病灶的位置。其他成像方法仅显示为稳定瘢痕灶。抗体扫描指导了该肿瘤病灶的手术切除，γ计数显示该病灶的抗体活性比正常肺组织高10倍。这种方法可能有助于检测人绒毛膜促性腺激素β亚基水平升高患者隐匿的妊娠滋养细胞肿瘤病灶以进行手术切除，目前正在进一步评估中。
