抗人绒毛膜促性腺激素小鼠单克隆抗体（W14A）的制备及特性
Preparation and properties of mouse monoclonal antibody (W14A) to human chorionic gonadotropin.
作者信息
Searle F, Partridge C S, Kardana A, Green A J, Buckley R G, Begent R H, Rawlins G A
出版信息
Int J Cancer. 1984 Apr 15;33(4):429-34. doi: 10.1002/ijc.2910330402.
PMID:6538552
Abstract
A mouse monoclonal antibody, W14A, has been prepared which reacts with intact human chorionic gonadotropin and its beta-subunit, showing less than 2% cross-reactivity towards the alpha-subunit and 0.5% cross-reactivity towards the beta-subunit of luteinizing hormone. The reagent is suitable for the radioimmunolocalization of choriocarcinoma and trophoblastic teratoma in humans. A preliminary radioimmunoassay has been developed.
摘要
已制备出一种小鼠单克隆抗体W14A，它能与完整的人绒毛膜促性腺激素及其β亚基发生反应，对促黄体生成素的α亚基交叉反应性小于2%，对其β亚基交叉反应性为0.5%。该试剂适用于人体绒毛膜癌和滋养层畸胎瘤的放射免疫定位。已开发出一种初步的放射免疫测定法。
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