Van Barneveld P W, Sleijfer D T, van der Mark T W, Mulder N H, Koops H S, Sluiter H J, Peset R
Am Rev Respir Dis. 1987 Jan;135(1):48-51. doi: 10.1164/arrd.1987.135.1.48.
In this study, long-term pulmonary complications of bleomycin were evaluated in 8 patients with bleomycin-induced pneumonitis (BIP). The lung function parameters: VC, alveolar volume, transfer factor for carbon monoxide of the lungs, diffusing capacity of the alveolocapillary membrane, and pulmonary capillary blood volume were studied in all patients for as long as 2 yr after the development of BIP. Perfusion scans with 133Xe and 99mTc were performed in these patients 2 yr after BIP developed. We concluded that if a patient survives the acute event of BIP, the pulmonary symptoms and the changes in these lung function parameters are completely reversible.
在本研究中，对8例博来霉素诱发肺炎（BIP）患者的博来霉素长期肺部并发症进行了评估。在所有患者中，自BIP发生后长达2年的时间里，研究了肺功能参数：肺活量（VC）、肺泡容积、肺一氧化碳转运因子、肺泡毛细血管膜弥散能力和肺毛细血管血容量。BIP发生2年后，对这些患者进行了¹³³Xe和⁹⁹ᵐTc灌注扫描。我们得出结论，如果患者在BIP急性事件中存活下来，肺部症状和这些肺功能参数的变化是完全可逆的。
