Lorenzoni F, Lunardi S, Liumbruno A, Ferri G, Madrigali V, Fiorentini E, Forli F, Berrettini S, Boldrini A, Ghirri P
Neonatal Unit and Neonatal Intensive Care Unit, Department of Clinical and Experimental Medicine, University Hospital of Pisa , Pisa , Italy and.
J Matern Fetal Neonatal Med. 2014 Oct;27(15):1589-93. doi: 10.3109/14767058.2013.871253. Epub 2014 Feb 19.
Congenital cytomegalovirus (CMV) infection affects many organs: reticuloendothelial and central nervous system are particularly involved. Congenital CMV infection is the leading cause of non-genetic sensorineural hearing loss. Hearing impairment can be present at birth or it can occur months or even years after birth. It is as well an important risk factor for antenatal stillbirth, preterm birth and small for gestational age (SGA) condition. For these reasons we should early identify congenital CMV infection investigating at least at risk newborns such as preterm or SGA babies given that a simple and standardized method for a large scale screening program is lacking. In our study, we found an association between congenital CMV infection and preterm births (3.03%) and with SGA condition (3.7%). Consequently, routine CMV urine detection should be performed at least in all babies born before 37 weeks of gestational age and in term SGA newborns.
先天性巨细胞病毒（CMV）感染会影响多个器官：网状内皮系统和中枢神经系统尤其受累。先天性CMV感染是导致非遗传性感音神经性听力损失的主要原因。听力障碍可在出生时就存在，也可能在出生后数月甚至数年出现。它也是产前死产、早产和小于胎龄儿（SGA）情况的重要危险因素。由于这些原因，鉴于缺乏一种用于大规模筛查项目的简单且标准化的方法，我们应该尽早识别先天性CMV感染，至少对高危新生儿进行调查，例如早产儿或小于胎龄儿。在我们的研究中，我们发现先天性CMV感染与早产（3.03%）以及小于胎龄儿情况（3.7%）之间存在关联。因此，至少应对所有孕周小于37周出生的婴儿以及足月小于胎龄儿新生儿进行常规CMV尿液检测。
