Cradeur Amber, Jackson Aaron, Ware Erin, Fourrier Torrey L, Mankekar Gauri
School of Medicine, Louisiana State University Health Shreveport, 1501, King's Highway, Shreveport, LA 71103, USA.
Library, Louisiana State University Health Shreveport, 1501, King's Highway, Shreveport, LA 71103, USA.
Children (Basel). 2025 May 8;12(5):613. doi: 10.3390/children12050613.
Congenital cytomegalovirus (cCMV) infection is a significant cause of pediatric hearing loss. However, the prevalence and characteristics of cCMV-related hearing loss remain unclear. : A comprehensive search of major databases (PubMed, Scopus, and Web of Science) was conducted to identify studies and reviews published between 2000 and 2024 that investigated cCMV infection, testing for cCMV, and pediatric hearing loss. Studies were included if they reported on the prevalence, characteristics, current policies, and recommendations for universal cCMV testing in newborns. : This review highlights key issues: cCMV is a significant and treatable cause of pediatric hearing loss; most cCMV-related hearing loss cases presented with bilateral and profound hearing impairment; and cCMV testing is performed only for babies who fail newborn hearing screening. : This narrative review highlights the significant association between cCMV infection and pediatric hearing loss. Currently, targeted cCMV testing is recommended for newborns who fail newborn hearing screening. Universal cCMV testing may facilitate early diagnosis and directed intervention and could be cost-effective in the long run.
先天性巨细胞病毒（cCMV）感染是小儿听力损失的一个重要原因。然而，cCMV相关听力损失的患病率和特征仍不清楚。：对主要数据库（PubMed、Scopus和科学网）进行了全面检索，以确定2000年至2024年间发表的调查cCMV感染、cCMV检测和小儿听力损失的研究及综述。如果研究报告了新生儿普遍进行cCMV检测的患病率、特征、现行政策和建议，则将其纳入。：本综述突出了关键问题：cCMV是小儿听力损失的一个重要且可治疗的原因；大多数cCMV相关听力损失病例表现为双侧严重听力障碍；并且仅对新生儿听力筛查未通过的婴儿进行cCMV检测。：本叙述性综述强调了cCMV感染与小儿听力损失之间的显著关联。目前，建议对新生儿听力筛查未通过的婴儿进行有针对性的cCMV检测。普遍进行cCMV检测可能有助于早期诊断和定向干预，从长远来看可能具有成本效益。
