Xu Meihong, Ma Yi, Xu Linlin, Xu Yajun, Li Yong
Department of Nutrition and Food Hygiene, School of Public Health, Peking University , Beijing, China .
J Med Food. 2013 Dec;16(12):1146-52. doi: 10.1089/jmf.2013.2790.
The aim of the present study was to evaluate dietary effects of dietary nucleotides (NTs) on developmental parameters in second-generation Sprague-Dawley rats. Experimental design was set up as six groups, including one control and five nucleotide administered groups, doses ranged from 0.01% to 1.28% nucleotides. First-generation (F0) rats were divided into two terms: (1) fed for 90-day study; (2) mated for offspring (F1). After weaning, each group of second-generation F1 rats was fed the control diet. Evaluating parameters were weight gain and food utilization ratios of rats, hematological and biochemical parameters, and organ pathology. The results showed that there was a greater weight gain and food utilization ratio in weaned rats (F0 and F1). Furthermore, weight gain and food utilization ratios were increased in the first 2 weeks of F1 male and the first week of F1 female rats. There were no significant changes in blood indicators of NT groups with the exception of decrease in aspartate aminotransferase and serum uric acid levels. Overall, it was demonstrated that NT supplements could promote the early growth and development at a 0.01% dose. Although NTs may have cumulative reproductive effects, they were safe even at a high-dose supplementation. Additionally, NT supplementation could promote restoration and optimize liver function.
本研究的目的是评估膳食核苷酸（NTs）对第二代斯普拉格-道利大鼠发育参数的膳食影响。实验设计分为六组，包括一组对照组和五组给予核苷酸的组，剂量范围为0.01%至1.28%的核苷酸。第一代（F0）大鼠分为两个阶段：（1）进行为期90天的喂养研究；（2）交配繁殖后代（F1）。断奶后，每组第二代F1大鼠喂食对照饮食。评估参数包括大鼠的体重增加和食物利用率、血液学和生化参数以及器官病理学。结果表明，断奶大鼠（F0和F1）的体重增加和食物利用率更高。此外，F1雄性大鼠的前2周和F1雌性大鼠的第1周体重增加和食物利用率有所提高。除了天冬氨酸转氨酶和血清尿酸水平降低外，NTs组的血液指标没有显著变化。总体而言，结果表明补充0.01%剂量的NTs可以促进早期生长发育。虽然NTs可能具有累积生殖效应，但即使高剂量补充也是安全的。此外，补充NTs可以促进肝功能的恢复和优化。
