高区域选择性的三组分 Domino Heck-Negishi 偶联反应在嘌呤的 C6 位官能化。
Highly regioselective three-component domino Heck-Negishi coupling reaction for the functionalization of purines at C6.
机构信息
Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, Henan Normal University , Xinxiang, Henan 453007, P. R. China.
出版信息
Org Lett. 2014 Jan 3;16(1):262-5. doi: 10.1021/ol4032683. Epub 2013 Dec 12.
A highly regioselective three-component domino Heck-Negishi coupling reaction has been developed. Organozinc reagents are used to trap an alkylpalladium intermediate of olefins for a first example in the domino Heck reaction. This reaction is applicable to acrylates (or acrylamides) and purine compounds, producing a series of novel purine compounds with carbon substituents at the C6 position in moderate to good yields.
发展了一种高区域选择性的三组分多米诺 Heck-Negishi 偶联反应。首次在多米诺 Heck 反应中，使用有机锌试剂捕获烯烃的烷基钯中间体。该反应适用于丙烯酸酯（或丙烯酰胺）和嘌呤化合物，以中等至良好的收率得到一系列新型嘧啶化合物，其 C6 位具有碳取代基。
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