van de Werken Maan, Booij Sanne H, van der Zwan J Esi, Simons Mirre J P, Gordijn Marijke C M, Beersma Domien G M
Department of Chronobiology, Centre for Life Sciences, University of Groningen , Groningen , the Netherlands.
Chronobiol Int. 2014 May;31(4):572-80. doi: 10.3109/07420528.2013.868472. Epub 2013 Dec 16.
Human cortisol levels follow a clear circadian rhythm. We investigated the contribution of alternation of sleep and wakefulness and the circadian clock, using forced desynchrony. Cortisol levels were best described by a multiplication of a circadian and a wake-time component. The human cortisol response is modulated by circadian phase. Exposure to stress at an unnatural phase, as in shift work, is predicted to result in abnormal cortisol levels. Health of shift workers may therefore improve when stress is reduced at times when the clock produces high stress sensitivity.
人类皮质醇水平呈现出明显的昼夜节律。我们利用强制失同步法研究了睡眠与清醒交替以及生物钟的作用。皮质醇水平最好用昼夜节律成分和清醒时间成分相乘来描述。人类皮质醇反应受昼夜节律相位调节。预计在非自然相位（如轮班工作时）暴露于压力下会导致皮质醇水平异常。因此，当在生物钟产生高压力敏感性的时段减轻压力时，轮班工作者的健康状况可能会得到改善。
