Abdullgaffar Badr, Al-Murbati Buthaina, Al-Falasi Mouza, Al-Otaibi Laila
Rashid hospital, Pathology, Dubai, United Arab Emirates.
Fetal Pediatr Pathol. 2014 Apr;33(2):98-103. doi: 10.3109/15513815.2013.864349. Epub 2013 Dec 11.
Langerhans cell histiocytosis (LCH) involvement of the gastrointestinal tract (GIT) is rare. The infiltrate in a colonic biopsy can be dissimilar to classic cytomorphologic features. It could be patchy, restricted to the subepithelial lamina propria and the lesional cells might have prominent nucleoli with lymphocytes-dominant background. The GIT manifestations could be confused with infectious, allergic, immunodeficiency and inflammatory bowel diseases. The rarity of GIT lesions, unawareness of some atypical endoscopic and histologic features might lead to false negative results. We report a case of LCH in an 11-month-old baby that was clinically unsuspected and histologically overlooked.
朗格汉斯细胞组织细胞增多症（LCH）累及胃肠道（GIT）较为罕见。结肠活检中的浸润情况可能与经典的细胞形态学特征不同。它可能呈斑片状，局限于上皮下固有层，病变细胞可能有明显的核仁，背景以淋巴细胞为主。GIT的表现可能会与感染性、过敏性、免疫缺陷性及炎症性肠病相混淆。GIT病变的罕见性、对一些非典型内镜和组织学特征的不了解可能导致假阴性结果。我们报告一例11个月大婴儿的LCH病例，该病例临床未被怀疑，组织学检查也被忽视。
