Wang Huan, Wang Yuesheng, Wang Ruifeng, Li Xiaoqin
Department of Gastroenterology, The Affiliated Children Hospital of Zhengzhou University, Henan Children Hospital, Zhengzhou, China.
Front Pediatr. 2021 Feb 24;9:545771. doi: 10.3389/fped.2021.545771. eCollection 2021.
Langerhans cell histiocytosis (LCH) is a rare disease with uncertain etiology. Langerhans cell histiocytosis with involvement of the gastrointestinal tract is rare and is typically identified in pediatric patients with systemic disease. The present study reports two infantile cases of LCH who initially presented with diarrhea, hematochezia, and rash and were histologically missed on the original examination of the colonic biopsy sections. The diagnosis of LCH was later verified through immunohistochemistry. By combining our experience and previous reports, the multiple hemorrhagic spots of the colorectal mucosa and narrowness and erosion of the distal duodenum might be suggestive manifestations of gastrointestinal involvement in LCH on endoscopic examination. This might be helpful for the early recognition of the disease.
朗格汉斯细胞组织细胞增多症（LCH）是一种病因不明的罕见疾病。累及胃肠道的朗格汉斯细胞组织细胞增多症很罕见，通常在患有全身性疾病的儿科患者中发现。本研究报告了两例婴儿LCH病例，最初表现为腹泻、便血和皮疹，在结肠活检切片的原始检查中组织学诊断遗漏。LCH的诊断后来通过免疫组织化学得到证实。结合我们的经验和既往报道，结直肠黏膜的多发出血点以及十二指肠远端的狭窄和糜烂可能是LCH胃肠道受累在内镜检查中的提示性表现。这可能有助于疾病的早期识别。
