ZJU-NHU United R&D Center, Department of Chemistry, Zhejiang University , Hangzhou 310027, China.
Org Lett. 2014 Jan 3;16(1):46-9. doi: 10.1021/ol402921w. Epub 2013 Dec 13.
A novel palladium-catalyzed ortho-C(sp(2))-H olefination protocol has been developed by the use of sulfoxide as the directing group. Importantly, relatively remote coordination can be accessed to achieve the ortho olefination of benzyl, 2-arylethyl, and 3-arylpropenyl sulfoxide substrates, and the olefinated sulfoxide can be easily transformed to other functionalities.
一种新型的钯催化的邻位 C(sp(2))-H 烯烃化反应协议已经通过使用亚砜作为导向基团来开发。重要的是，可以通过相对远程的配位来实现苄基、2-芳基乙基和 3-芳基丙烯基亚砜底物的邻位烯烃化，并且可以将烯烃化的亚砜容易地转化为其他官能团。
