Hu Guohua, Zhang Lei, Rong Yefei, Ni Xiaoling, Sun Yihong
Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Curr Drug Metab. 2014 Jan;15(1):14-22. doi: 10.2174/1389200214666131211155613.
Green tea is one of the most popular beverages around the world. For several decades, numerous epidemiological, preclinical and clinical studies have demonstrated that green tea polyphenols (GTPs), especially epigallocatechin-3-gallate (EGCG) have cancer-preventing effects on various cancers. In this review, we present inhibition of carcinogenesis in different animal models by GTPs or EGCG, including prostate cancer, bladder cancer, breast cancer, intestinal cancer, colon cancer, gastric cancer, lung cancer, oral cancer and skin cancer. In vitro studies showed that GTPs/EGCG potently induces apoptosis, cell cycle arrest and suppresses metastasis in tumor cells but not in their normal cell counterparts. The molecular mechanisms of these activities are discussed in detail to elucidate GTPs/EGCG downstream carcinogenesis signaling pathways and their values of perspective of chemoprevention and treatment for cancers.
绿茶是全球最受欢迎的饮品之一。几十年来，众多流行病学、临床前和临床研究表明，绿茶多酚（GTPs），尤其是表没食子儿茶素-3-没食子酸酯（EGCG）对多种癌症具有防癌作用。在本综述中，我们介绍了GTPs或EGCG在不同动物模型中对致癌作用的抑制，包括前列腺癌、膀胱癌、乳腺癌、肠癌、结肠癌、胃癌、肺癌、口腔癌和皮肤癌。体外研究表明，GTPs/EGCG能有效诱导肿瘤细胞凋亡、细胞周期停滞并抑制其转移，而对正常细胞则无此作用。我们详细讨论了这些活性的分子机制，以阐明GTPs/EGCG下游的致癌信号通路及其在癌症化学预防和治疗方面的潜在价值。
