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P物质可能是有害机械刺激的调节因子而非递质的证据。

Evidence that substance P may be a modulator rather than a transmitter of noxious mechanical stimulation.

作者信息

Sweeney M I, Sawynok J

出版信息

Can J Physiol Pharmacol. 1986 Oct;64(10):1324-7. doi: 10.1139/y86-224.

DOI:10.1139/y86-224
PMID:2433009
Abstract

Substance P (SP), injected intrathecally, produced a dose-related increase in responsiveness (hyperalgesia) in a pressure test for nociceptive thresholds. Pretreatment with two doses of SP produced complete desensitization to this response but did not alter base-line responsiveness. The hyperalgesic response to SP and the lack of change in base line following desensitization to SP suggest a modulator rather than a transmitter role for SP in the transmission of noxious mechanical stimulation.

摘要

鞘内注射P物质（SP），在伤害性阈值的压力测试中可产生剂量相关的反应性增加（痛觉过敏）。预先给予两剂SP可使对此反应产生完全脱敏，但不改变基线反应性。对SP的痛觉过敏反应以及对SP脱敏后基线无变化表明，SP在有害机械刺激的传递中起调节作用而非递质作用。

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引用本文的文献

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J Neurosci. 2003 Mar 1;23(5):1816-24. doi: 10.1523/JNEUROSCI.23-05-01816.2003.
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Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):1029-34. doi: 10.1073/pnas.012598599.
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Sufentanil, morphine, met-enkephalin, and kappa-agonist (U-50,488H) inhibit substance P release from primary sensory neurons: a model for presynaptic spinal opioid actions.
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Anesthesiology. 1989 Apr;70(4):672-7. doi: 10.1097/00000542-198904000-00022.