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Intrathecal capsaicin depletes substance P in the rat spinal cord and produces prolonged thermal analgesia.

作者信息

Yaksh T L, Farb D H, Leeman S E, Jessell T M

出版信息

Science. 1979 Oct 26;206(4417):481-3. doi: 10.1126/science.228392.

Abstract

A single intrathecal injection of capsaicin depletes substance P from primary sensory neurons and causes a prolonged increase in the thermal and chemical pain thresholds of the rat but no apparent change in responses to noxious mechanical stimuli.

摘要

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