Soni Sandeep, Breslin Nancy, Cheerva Alexandra
Division of Heme/Onc/BMT, Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA.
Pediatr Transplant. 2014 Mar;18(2):E41-3. doi: 10.1111/petr.12201. Epub 2013 Dec 16.
Unrelated umbilical CB transplant for class 3 β-thalassemia major is associated with an increased risk of mortality and non-engraftment. We describe two patients who underwent successful unrelated umbilical CB transplant using a novel reduced-toxicity preparative regimen. This regimen may be sufficiently immunosuppressive and myeloablative to ensure engraftment with reduced risks of toxicity and mortality. Close monitoring of HHV-6 viral load is advised for patients undergoing transplant with this regimen.
无关供者脐血移植治疗重型β地中海贫血3级与死亡和未植入风险增加相关。我们描述了两名患者，他们使用一种新型低毒性预处理方案成功接受了无关供者脐血移植。该方案可能具有足够的免疫抑制和清髓作用，以确保植入，同时降低毒性和死亡风险。建议对接受该方案移植的患者密切监测HHV-6病毒载量。
