阿立哌唑增效治疗精神分裂症氯氮平相关的强迫症状。
Aripirazole augmentation in clozapine-associated obsessive-compulsive symptoms in schizophrenia.
机构信息
Department of Psychiatry, Uskudar University, Neuropsychiatry Istanbul Hospital, Alemdag Caddesi Site Yolu No:29, Umraniye, Istanbul, Turkey.
出版信息
Ann Gen Psychiatry. 2013 Dec 12;12(1):40. doi: 10.1186/1744-859X-12-40.
Abstract
OBJECTIVE
Patients with schizophrenia often experience comorbid obsessive-compulsive symptoms. Within these patients, a significant subgroup developed secondary obsessive-compulsive symptoms during treatment with clozapine.
METHOD
In this paper, we report on four cases in which adjunctive therapy with aripiprazole was tested to alleviate obsessive-compulsive symptoms in schizophrenia.
RESULTS
All four patients had a significant improvement in obsessive-compulsive symptoms. The combination of clozapine and aripiprazole was well tolerated.
CONCLUSION
This case series demonstrates the clinical efficacy of aripiprazole adjunctive therapy with clozapine in schizophrenic patients with comorbid obsessive-compulsive symptoms. Larger-sampled and controlled studies are required in order to test and confirm these observations.
摘要
目的
精神分裂症患者常伴有强迫症症状。在这些患者中，有相当一部分在接受氯氮平治疗期间出现继发性强迫症症状。
方法
本文报告了 4 例使用阿立哌唑辅助治疗精神分裂症伴强迫症的病例。
结果
所有 4 例患者的强迫症症状均有显著改善。氯氮平和阿立哌唑联合使用耐受性良好。
结论
本病例系列研究表明，阿立哌唑辅助氯氮平治疗精神分裂症伴强迫症症状的患者具有临床疗效。需要更大样本量和对照研究来检验和证实这些观察结果。
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