Stein P, Rosalki S B, Foo A Y, Hjelm M
Clin Chem. 1987 Feb;33(2 Pt 1):313-8.
Clinical and biochemical features of transient hyperphosphatasemia of infancy and early childhood are reviewed in 21 patients we have studied and in a further 93 cases reported in the literature. The diagnosis is suggested by the finding of an increased activity of alkaline phosphatase (EC 3.1.3.1) in plasma, typically more than fivefold the adult upper reference limit, in a child under five years of age, without evidence of liver or bone disease. The condition is confirmed by the presence of a characteristic pattern of alkaline phosphatase isoenzymes and by the normalization of the enzyme's activity in plasma within approximately three months. The etiology of the condition and possible mechanisms of the enzyme increase are discussed.
我们对21例婴幼儿期短暂性高磷酸酶血症患者的临床和生化特征进行了回顾，并结合文献中另外93例病例进行分析。诊断依据为：5岁以下儿童血浆中碱性磷酸酶（EC 3.1.3.1）活性升高，通常超过成人参考上限的五倍，且无肝脏或骨骼疾病证据。通过碱性磷酸酶同工酶的特征性模式以及血浆中该酶活性在大约三个月内恢复正常得以确诊。文中还讨论了该病的病因及酶活性增加的可能机制。
